In the days and weeks before they die, fifteen to twenty percent of
terminally ill cancer patients receive “palliative chemotherapy.” Their
doctors do not expect chemo to cure them. Why then, do they receive it?
In “The Role of Chemotherapy at the End of Life: When Is Enough, Enough?",
Drs. Sarah Elizabeth Harrington and Thomas J. Smith explain:
“Chemotherapy for metastatic solid tumors such as lung, breast, colon,
or prostate cancer rarely if ever cures patients. The indication for
such chemotherapy is to improve disease-free or overall survival,
relieve symptoms, and improve quality of life.”
In the article, which appeared in the most recent issue of JAMA,
Harrington and Smith tell the story of Mr.L., a 56-year old businessman
who is determined to fight the lung cancer that has spread to his spine
and brain. Even when his oncologist recommends that it is time for Mr.
L. to shift over to hospice care, Mr. L. refuses.
“You know my husband was extremely determined to remain positive,
and he never was going to give in [to the fact] that this could
eventually kill him,” his wife reports proudly. “It didn't really dawn
on my husband that he was going to die until he was in the hospital
with pneumonia, which was two weeks before he passed away.”
Near the very end of Mr. L’s life, the hospital staff called in a
palliative care specialist to help Mr. L. face the fact that he was
dying and to consider his options.
Chemotherapy had helped him during the first eight months after he
was diagnosed, but during the last six months of his life, as his
condition deteriorated, the medical staff felt that because the cancer
had spread to his brain, “he was not making informed choices and
had lost opportunities to do other important things with his remaining
time while pursuing further chemotherapies and clinical trials.”
The palliative care specialist believed that he should have been
called in sooner. Arguably, Mr. L. needed an oncologist like Dr. Peter
Eisenberg, who I quote in part 1 of this post: “Most oncologists don’t
talk about the important stuff. They just say, ‘In six to eight months,
if this doesn’t work, we’ll try Plan B…”
By contrast, Eisenberg levels
with his patients: “I ask them: ‘How do you want to spend the rest of
your foreshortened life? Do you want to spend it hanging out with me
and my staff [going through another round of chemo]—or do you have
something else that you want to do?’”